Longevity Clinics Guide
Menu

Method and trust

How we check licencesReview policyFor clinicsAboutDisclosuresContact

Treatments · 22 clinics in 5 countries · checked 21 Oct 2026

Plasma exchange: evidence, regulation and where it is offered

Therapeutic plasma exchange removes the liquid part of the blood and replaces it with a substitute fluid. Our evidence label for it is Depends on use. Established for some medical conditions, unproven as a longevity treatment. 22 clinics we list offer it, in the United States, the United Kingdom, Thailand, the United Arab Emirates and Mexico.

In plasma exchange, the plasma is separated from the blood cells and removed. The cells are returned with a replacement fluid, such as albumin solution or donated plasma. A session usually takes one to two hours (Cambridge University Hospitals). It is not the same as an infusion of plasma from young donors, which the US Food and Drug Administration (FDA) has warned against (see below).

DEPENDS ON USE

What the evidence says

Prescription status: not marked prescription-only in our data.

Hospitals use plasma exchange for some nerve, immune and blood conditions. The American Society for Apheresis lists it as a first-line treatment for conditions such as Guillain-Barré syndrome and thrombotic thrombocytopenic purpura, a rare blood disorder (ASFA guidelines, 2023).

For ageing, research is at an early stage. A 2025 trial in 44 people in their 60s compared plasma exchange with a sham treatment over a few months (Lifespan.io). It measured blood markers, "biological age" tests and some physical tests, such as balance and strength. The researchers called the results early data. The changes were largest after the first three sessions, and the study was supported by a company that offers the treatment (Buck Institute, 2025).

Regulators and prescription status

In February 2019 the FDA said there is no proven clinical benefit from infusions of plasma from young donors, which were being marketed for conditions from normal ageing to memory loss. In December 2024 it said again that "young plasma" is not approved to treat any condition or to improve health and wellness (AABB, 2024).

Depends on use means: Established for some medical conditions, unproven as a longevity treatment.

What regulators say

CountryNoteSource
United StatesIn February 2019 the FDA said infusions of plasma from young donors have no proven clinical benefit for normal ageing, memory loss or other conditions they were marketed for.FDA statement, 19 February 2019
United KingdomNo regulator statement recorded yet.
ThailandNo regulator statement recorded yet.
United Arab EmiratesNo regulator statement recorded yet.
MexicoNo regulator statement recorded yet.

Where it is offered

New York3 clinics
Los Angeles6 clinics
Miami4 clinics
London1 clinic
Bangkok1 clinic
Dubai1 clinic
Cancún and Riviera Maya2 clinics
Puerto Vallarta and Riviera Nayarit4 clinics

Published prices

No price that may be shown is published by the clinics we list.

Safety and questions to ask

During plasma exchange, some people feel faint or dizzy (Cambridge University Hospitals). The medicine used to stop the blood clotting, and some replacement fluids, can cause tingling around the lips or in the fingers and toes. Replacement plasma can cause a rash or fever and, rarely, a serious lung reaction. Repeated sessions can lower the clotting factors in the blood.

  1. Who carries out the procedure, and in what kind of facility?
  2. Why is it proposed for me, and what will be measured?
  3. Which replacement fluid will be used, and what are its risks?
  4. How many sessions are proposed, and what does each include?
  5. Who do I call if I feel unwell afterwards?

Sources